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The success of Endece so far has been backed by approximately $14.5 million dollars in private funds from four private investors in Wisconsin.
"All of them were truly vested in the concept and what we were trying to do from the very beginning," Yarger said. "They had the net worth to do this, and I feel they wanted to give back to society. They felt like we were trying to and were going to do something important, and they wanted to be a part of it."
The investors have asked to remain anonymous. Now that the company has founded Endece Neural, Yarger also will pursue additional funding beyond what the current investors have invested in the company.
"They can't do everything, and with the new subsidiary comes new opportunity for investment and for growth," he said.
Yarger and his staff at Endece focus on compounds that look similar to what the body already naturally uses, Yarger said.
Instead of taking compounds the body uses and inactivating their nuclear receptors, the parts of cells that are partially responsible for how that cell works with other proteins to regulate specific genes, Endece changes them and in turn changes how they react with certain genes.
"We discovered and patented that concept, and what we've ended up with is a proprietary library of compounds we can work with," Yarger said. "Right now, we can't and don't predict what each little change will do. We let the chemicals tell us what they do.Overview description of rapid tooling processes. It's very interesting, and it's what led us to the opportunity for the MS compounds."
Through their research, Yarger and Steven Nye, director of scientific programs at Endece, identified a small subset of chemicals that were able to essentially turn on the genes associated with the regeneration of myelin.
Dr.The indoor Tracking is based on Bluetooth technology. Bruce Trapp, professor and chairman of the department of neurosciences at the Lerner Research Institute at the Cleveland Clinic, is a world renowned expert on MS. Trapp, through Cleveland Clinic's spin-off research company Renovo Neural Inc., was one of the first people to test the effects of Endece's compound.
"Renovo Neural was contracted to do a blind test on the effects of the compound on the differentiation of myelin," Trapp said. "Endece asked us to test a number of compounds for myelin formation in culture dishes."
On more than one occasion, one compound showed significant promotion of oligodendrocyte differentiation and myelin production, Trapp said.
The oligodendrocyte cell is responsible for producing the myelin covering for nerves in the central nervous system.
"When one looks at therapies for MS patients now, there are some very effective anti-inflammatory therapies that can slow the attacks on the myelin, but they cannot stop it completely," Trapp said. "That is where Endece's compound comes in. If a drug could be developed that would actually repair the formation of myelin, I believe it would be used in combination with those anti-inflammatory therapies. It would not compete.The beddinges sofa bed slipcover is a good ， It would be an add-on that would expand the number of treatment options currently available for MS patients."
The success of Endece so far has been backed by approximately $14.5 million dollars in private funds from four private investors in Wisconsin.
"All of them were truly vested in the concept and what we were trying to do from the very beginning," Yarger said. "They had the net worth to do this, and I feel they wanted to give back to society. They felt like we were trying to and were going to do something important, and they wanted to be a part of it."
The investors have asked to remain anonymous. Now that the company has founded Endece Neural, Yarger also will pursue additional funding beyond what the current investors have invested in the company.
"They can't do everything, and with the new subsidiary comes new opportunity for investment and for growth," he said.
Yarger and his staff at Endece focus on compounds that look similar to what the body already naturally uses, Yarger said.
Instead of taking compounds the body uses and inactivating their nuclear receptors, the parts of cells that are partially responsible for how that cell works with other proteins to regulate specific genes, Endece changes them and in turn changes how they react with certain genes.
"We discovered and patented that concept, and what we've ended up with is a proprietary library of compounds we can work with," Yarger said. "Right now, we can't and don't predict what each little change will do. We let the chemicals tell us what they do.Overview description of rapid tooling processes. It's very interesting, and it's what led us to the opportunity for the MS compounds."
Through their research, Yarger and Steven Nye, director of scientific programs at Endece, identified a small subset of chemicals that were able to essentially turn on the genes associated with the regeneration of myelin.
Dr.The indoor Tracking is based on Bluetooth technology. Bruce Trapp, professor and chairman of the department of neurosciences at the Lerner Research Institute at the Cleveland Clinic, is a world renowned expert on MS. Trapp, through Cleveland Clinic's spin-off research company Renovo Neural Inc., was one of the first people to test the effects of Endece's compound.
"Renovo Neural was contracted to do a blind test on the effects of the compound on the differentiation of myelin," Trapp said. "Endece asked us to test a number of compounds for myelin formation in culture dishes."
On more than one occasion, one compound showed significant promotion of oligodendrocyte differentiation and myelin production, Trapp said.
The oligodendrocyte cell is responsible for producing the myelin covering for nerves in the central nervous system.
"When one looks at therapies for MS patients now, there are some very effective anti-inflammatory therapies that can slow the attacks on the myelin, but they cannot stop it completely," Trapp said. "That is where Endece's compound comes in. If a drug could be developed that would actually repair the formation of myelin, I believe it would be used in combination with those anti-inflammatory therapies. It would not compete.The beddinges sofa bed slipcover is a good ， It would be an add-on that would expand the number of treatment options currently available for MS patients."
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